| Ghana Music Top 10 Countdown brought to you by Sprog Store. |
| Week #42 October 23rd, 2021. | P | W | L | |
| 1. | Touch It by KiDi | 1 | 20 | 1 |
| 2. | Second Sermon by Black Sherif | 1 | 14 | 2 |
| 3. | Thy Grace by Kofi Kinaata | 3 | 15 | 4 |
| 4. | Praise by Fameye | 1 | 21 | 3 |
| 5. | Heat by Wendy Shay ft. Shay Gang | 5 | 5 | 5 |
| 6. | Je M’appelle by Darkovibes ft. Davido | 6 | 3 | 7 |
| 7. | Echoke by Sefa ft. Mr. Drew | 1 | 21 | 6 |
| 8. | Abodie by Captain Planet ft. Kuami Eugene | 8 | 2 | 9 |
| 9. | Fine Wine by R2Bees ft. King Promise | 3 | 16 | 8 |
| 10. | Enjoyment Minister by D-Black ft. Quamina MP & Stonebwoy | 5 | 21 | 10 |
| P = Peaked | W = Weeks on Chart | L = Last Week’s Position |
| #top10GH Compiled every week by Ghana Music. |
