| Week #49 December 11th, 2021. | P | W | L | |
| 1. | Abotrɛ by Amerado ft. Black Sherif | 1 | 6 | 2 |
| 2. | Je M’appelle by Darkovibes ft. Davido | 1 | 10 | 1 |
| 3. | Jonathan by AK Songstress | 3 | 4 | 3 |
| 4. | Abodie by Captain Planet ft. Kuami Eugene | 2 | 9 | 4 |
| 5. | Heat by Wendy Shay ft. Shay Gang | 4 | 12 | 5 |
| 6. | Thy Grace 2 by Kofi Kinaata | 6 | 4 | 6 |
| 7. | Eboso by R2Bees | 7 | 2 | 10 |
| 8. | Victory by Akesse Brempong ft. Johnny Haick | 8 | 4 | 9 |
| 9. | Second Sermon Remix by Black Sherif ft. Burna Boy | 9 | 1 | – |
| 10. | Jah Jehovah by Phaize ft. Fameye | 10 | 1 | – |
| P = Peaked | W = Weeks on Chart | L = Last Week’s Position |
| #top10GH Compiled every week by Ghana Music. |
